| First Author | Govindarajan V | Year | 2000 |
| Journal | Dev Biol | Volume | 225 |
| Issue | 1 | Pages | 188-200 |
| PubMed ID | 10964474 | Mgi Jnum | J:64331 |
| Mgi Id | MGI:1889108 | Doi | 10.1006/dbio.2000.9812 |
| Citation | Govindarajan V, et al. (2000) Endogenous and ectopic gland induction by FGF-10. Dev Biol 225(1):188-200 |
| abstractText | FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis. Copyright 2000 Academic Press. |
