| First Author | Neznanov N | Year | 1999 |
| Journal | Cancer Res | Volume | 59 |
| Issue | 17 | Pages | 4242-6 |
| PubMed ID | 10485465 | Mgi Jnum | J:57272 |
| Mgi Id | MGI:1344162 | Citation | Neznanov N, et al. (1999) A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice. Cancer Res 59(17):4242-6 |
| abstractText | Heterozygous female mice carrying a targeted mutation of the Ets2 transcription factor gene were mated with a mouse strain that develops mammary tumors due to the expression of the polyoma virus middle T oncogene. Tumors from females with only one wild-type Ets2 gene were approximately one-half the size of tumors from controls. The smaller size of the tumors was correlated with a more differentiated state of early hyperplastic growths and not to differential growth of the frank tumors or to decreased middle T gene expression. Ets2 may regulate the progression of these aggressive mammary tumors. |
