| First Author | Böttcher RT | Year | 2012 |
| Journal | Nat Cell Biol | Volume | 14 |
| Issue | 6 | Pages | 584-92 |
| PubMed ID | 22561348 | Mgi Jnum | J:185558 |
| Mgi Id | MGI:5429144 | Doi | 10.1038/ncb2501 |
| Citation | Bottcher RT, et al. (2012) Sorting nexin 17 prevents lysosomal degradation of beta1 integrins by binding to the beta1-integrin tail. Nat Cell Biol 14(6):584-92 |
| abstractText | Integrin functions are controlled by regulating their affinity for ligand, and by the efficient recycling of intact integrins through endosomes. Here we demonstrate that the Kindlin-binding site in the beta1-integrin cytoplasmic domain serves as a molecular switch enabling the sequential binding of two FERM-domain-containing proteins in different cellular compartments. When beta1 integrins are at the plasma membrane, Kindlins control ligand-binding affinity. However, when they are internalized, Kindlins dissociate from integrins and sorting nexin 17 (SNX17) is recruited to free beta1-integrin tails in early endosomes to prevent beta1-integrin degradation, leading to their recycling back to the cell surface. Our results identify SNX17 as a beta1-integrin-tail-binding protein that interacts with the free Kindlin-binding site in endosomes to stabilize beta1 integrins, resulting in their recycling to the cell surface where they can be reused. |
