| First Author | Masuda T | Year | 2022 |
| Journal | Nature | Volume | 604 |
| Issue | 7907 | Pages | 740-748 |
| PubMed ID | 35444273 | Mgi Jnum | J:330324 |
| Mgi Id | MGI:7367043 | Doi | 10.1038/s41586-022-04596-2 |
| Citation | Masuda T, et al. (2022) Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature 604(7907):740-748 |
| abstractText | All tissue-resident macrophages of the central nervous system (CNS)-including parenchymal microglia, as well as CNS-associated macrophages (CAMs(1)) such as meningeal and perivascular macrophages(2-7)-are part of the CNS endogenous innate immune system that acts as the first line of defence during infections or trauma(2,8-10). It has been suggested that microglia and all subsets of CAMs are derived from prenatal cellular sources in the yolk sac that were defined as early erythromyeloid progenitors(11-15). However, the precise ontogenetic relationships, the underlying transcriptional programs and the molecular signals that drive the development of distinct CAM subsets in situ are poorly understood. Here we show, using fate-mapping systems, single-cell profiling and cell-specific mutants, that only meningeal macrophages and microglia share a common prenatal progenitor. By contrast, perivascular macrophages originate from perinatal meningeal macrophages only after birth in an integrin-dependent manner. The establishment of perivascular macrophages critically requires the presence of arterial vascular smooth muscle cells. Together, our data reveal a precisely timed process in distinct anatomical niches for the establishment of macrophage subsets in the CNS. |
