| First Author | Rondi-Reig L | Year | 2006 |
| Journal | J Neurosci | Volume | 26 |
| Issue | 15 | Pages | 4071-81 |
| PubMed ID | 16611824 | Mgi Jnum | J:108400 |
| Mgi Id | MGI:3623866 | Doi | 10.1523/JNEUROSCI.3408-05.2006 |
| Citation | Rondi-Reig L, et al. (2006) Impaired sequential egocentric and allocentric memories in forebrain-specific-NMDA receptor knock-out mice during a new task dissociating strategies of navigation. J Neurosci 26(15):4071-81 |
| abstractText | The hippocampus is considered to play a role in allocentric but not in egocentric spatial learning. How does this view fit with the emerging evidence that the hippocampus and possibly related cortical areas are necessary for episodic-like memory, i.e., in all situations in which events need to be spatially or sequentially organized? Are NMDA receptor-dependent mechanisms crucial for the acquisition of spatiotemporal relationships? To address this issue, we used knock-out (KO) mice lacking hippocampal CA1 NMDA receptors and presenting a reduction of these receptors in the deep cortical layers (NR1-KO mice). A new task (the starmaze) was designed, allowing us to distinguish allocentric and sequential-egocentric memories. NR1-KO mice were impaired in acquiring both types of memory. Our findings suggest that memories composed of multiple spatiotemporal events require intact NMDA receptors-dependent mechanisms in CA1 and possibly in the deep cortical layers. |
