| First Author | Sakamoto T | Year | 2002 |
| Journal | Brain Res Mol Brain Res | Volume | 102 |
| Issue | 1-2 | Pages | 113-7 |
| PubMed ID | 12191501 | Mgi Jnum | J:109322 |
| Mgi Id | MGI:3628711 | Doi | 10.1016/s0169-328x(02)00189-4 |
| Citation | Sakamoto T, et al. (2002) Mutation of NMDA receptor subunit epsilon 1: effects on audiogenic-like seizures induced by electrical stimulation of the inferior colliculus in mice. Brain Res Mol Brain Res 102(1-2):113-7 |
| abstractText | It has been shown that the N-methyl-D-asparate (NMDA) receptor in the inferior colliculus is involved in the induction of audiogenic seizures (AGS). In the present study we examined audiogenic-like seizure susceptibility in GluR epsilon 1 null KO adult mice (n=32) and wild-type adult mice (n=28) by electrically stimulating the inferior colliculus (IC). Threshold current intensities of the GluR epsilon 1 KO mice for wild running, clonic and tonic seizures were higher than those of wild-type mice. In addition, the incidence rates of each seizure syndrome in GluR epsilon 1 KO mice were lower than in wild-type mice at each current intensity. These results show that GluR epsilon 1 KO mice were more resistant to audiogenic-like seizures induced by stimulating the IC. Thus, our findings suggest that the GluR epsilon 1 subunit plays an important role in regulating AGS. |
