| First Author | Olejnickova V | Year | 2024 |
| Journal | Dev Dyn | Volume | 253 |
| Issue | 1 | Pages | 78-90 |
| PubMed ID | 36400745 | Mgi Jnum | J:344070 |
| Mgi Id | MGI:7571630 | Doi | 10.1002/dvdy.552 |
| Citation | Olejnickova V, et al. (2024) Development of ventricular trabeculae affects electrical conduction in the early endothermic heart. Dev Dyn 253(1):78-90 |
| abstractText | BACKGROUND: The ventricular trabeculae play a role, among others, in the impulse spreading in ectothermic hearts. Despite the morphological similarity with the early developing hearts of endotherms, this trabecular function in mammalian and avian embryos was poorly addressed. RESULTS: We simulated impulse propagation inside the looping ventricle and revealed delayed apical activation in the heart with inhibited trabecular growth. This finding was corroborated by direct imaging of the endocardial surface showing early activation within the trabeculae implying preferential spreading of depolarization along with them. Targeting two crucial pathways of trabecular formation (Neuregulin/ErbB and Nkx2.5), we showed that trabecular development is also essential for proper conduction patterning. Persistence of the slow isotropic conduction likely contributed to the pumping failure in the trabeculae-deficient hearts. CONCLUSIONS: Our results showed the essential role of trabeculae in intraventricular impulse spreading and conduction patterning in the early endothermic heart. Lack of trabeculae leads to the failure of conduction parameters differentiation resulting in primitive ventricular activation with consequent impact on the cardiac pumping function. |
