| Primary Identifier | MGI:1913092 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Myf6 |
| Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<+> |
| Is Recombinase | false | Is Wild Type | false |
| description | Studies have shown that Myf6 may regulate Myf5 expression by a cis-acting mechanism and that the skeletal abnormalities seen in Myf6 homozygotes may result from a decrease or lack of Myf5 expression. This allele (Myf6tm1Eno) does not display reduced expression of Myf5 and thus may exhibit the true Myf6 null phenotype unlike other Myf6 alleles that may have phenotypes resulting from the reduction or lack of Myf5 (J:26105, J:42453). |
| molecularNote | A neomycin cassette was inserted into the Myf6 gene such that all sequences 3' of codon 69 are removed. These deleted sequences encode the bHLH region of the 1st exon and the entire carboxyl terminus. Myf5 expression does not appear to be altered in this allele. |
