| First Author | Kitamura Y | Year | 1998 |
| Journal | Neurosci Lett | Volume | 255 |
| Issue | 1 | Pages | 57-60 |
| PubMed ID | 9839726 | Mgi Jnum | J:54743 |
| Mgi Id | MGI:1335790 | Doi | 10.1016/s0304-3940(98)00714-9 |
| Citation | Kitamura Y, et al. (1998) Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse. Neurosci Lett 255(1):57-60 |
| abstractText | We examined kainic acid (KA)-induced neuronal death and changes in glial cells in p53-deficient (p53-/-) and wild-type (p53+/+) mice which were CBA and C57BL/6 background. The p53-/- mouse exhibited a KA-induced loss of CA3 pyramidal neurons similar to that in wild-type mouse. Before neuronal death, c-Jun protein was expressed, phosphorylated and translocated into several nuclei of CA3 pyramidal neurons. In p53-/- mouse, microglial activation was slightly faster and more continuous after 1-7 days than that in p53+/+ mouse. On the other hand, p53-/- astrocytes were relatively resistant to KA cytotoxicity, and marked astrocytosis also occurred after 7 days. These observations suggest that p53-null mutation may influence the activation and proliferation of glial cells rather than neuronal death. |
