| First Author | Chao C | Year | 2000 |
| Journal | J Immunol | Volume | 164 |
| Issue | 1 | Pages | 345-9 |
| PubMed ID | 10605029 | Mgi Jnum | J:112434 |
| Mgi Id | MGI:3656332 | Doi | 10.4049/jimmunol.164.1.345 |
| Citation | Chao C, et al. (2000) Rescue of defective T cell development and function in Atm-/- mice by a functional TCR alpha beta transgene. J Immunol 164(1):345-9 |
| abstractText | The Atm-/- mice recapitulate most of the defects observed in ataxia-telangiectasia (A-T) patients, including a high incidence of lymphoid tumors and immune defects characterized by defective T cell differentiation, thymus hypoplasia, and defective T-dependent immune responses. To understand the basis of the T cell developmental defects in Atm-/- mice, a functional TCR alpha beta transgene was introduced into these mutant mice. Analysis of the Atm-/-TCR alpha beta+ mice indicated that the transgenic TCR alpha beta can rescue the defective T cell differentiation and partially rescue the thymus hypoplasia in Atm-/- mice, indicating that thymocyte positive selection is normal in the Atm-/- mice. In addition, cell cycle analysis of the thymocytes derived from Atm-/-TCR alpha beta+ and control mice suggested that Atm is involved in the thymocyte expansion. Finally, evaluation of the T-dependent immune responses in Atm-/-TCR alpha beta+ mice indicated that Atm is dispensable for normal T cell function. Therefore, the defective T-dependent immune responses in Atm-/- mice must be secondary to greatly reduced T cell numbers in these mutant mice. |
