Primary Identifier | MGI:1926357 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(BMP4)6Blh |
Inheritance Mode | Not Specified | Strain of Origin | (C57BL/6 x DBA/2)F1 |
Is Recombinase | false | Is Wild Type | false |
description | Allele Notes: Thirteen founder mice were obtained using this transgene construct, but only line 6 was fertile and used in most experiments. Founders 1-5 displayed a severe phenotype that included cranifacial abnormalies and died perinatally. Founders 6-11 had a more moderate phenotype and are described in the paper. Founders 12 and 13 did not express the transgene. |
molecularNote | Overexpression of the human BMP4 gene in nasal epithelium, oral mucosa, and the outer root sheath of hair and whisker follicles under the control of the bovine cytokeratin IV* promoter. |