| First Author | Banach-Petrosky W | Year | 2007 |
| Journal | Cancer Res | Volume | 67 |
| Issue | 19 | Pages | 9089-96 |
| PubMed ID | 17909013 | Mgi Jnum | J:125506 |
| Mgi Id | MGI:3758985 | Doi | 10.1158/0008-5472.CAN-07-2887 |
| Citation | Banach-Petrosky W, et al. (2007) Prolonged exposure to reduced levels of androgen accelerates prostate cancer progression in Nkx3.1; Pten mutant mice. Cancer Res 67(19):9089-96 |
| abstractText | In this report, we have investigated the relationship between androgen levels and prostate tumorigenesis in Nkx3.1; Pten mutant mice, a genetically engineered mouse model of human prostate cancer. By experimentally manipulating serum levels of testosterone in these mice for an extended period (i.e., 7 months), we have found that prolonged exposure of Nkx3.1; Pten mutant mice to androgen levels that are 10-fold lower than normal (the 'Low-T' group) resulted in a marked acceleration of prostate tumorigenesis compared with those exposed to androgen levels within the reference range (the 'Normal-T' group). We found that prostate tumors from the Low-T mutant mice share a similar gene expression profile as androgen-independent prostate tumors from these mutant mice, which includes the deregulated expression of several genes that are up-regulated in human hormone-refractory prostate cancer, such as Vav3 and Runx1. We propose that exposure to reduced androgens may promote prostate tumorigenesis by selecting for molecular events that promote more aggressive, hormone-refractory tumors. |
