| First Author | Hamilton-Williams EE | Year | 2003 |
| Journal | Proc Natl Acad Sci U S A | Volume | 100 |
| Issue | 11 | Pages | 6688-93 |
| PubMed ID | 12750472 | Mgi Jnum | J:83635 |
| Mgi Id | MGI:2662794 | Doi | 10.1073/pnas.1131954100 |
| Citation | Hamilton-Williams EE, et al. (2003) Beta cell MHC class I is a late requirement for diabetes. Proc Natl Acad Sci U S A 100(11):6688-93 |
| abstractText | Type 1 diabetes occurs as a result of an autoimmune attack on the insulin-producing beta cells. Although CD8 T cells have been implicated both early and late in this process, the requirement for direct interaction between these cells and MHC class I on the beta cells has not been demonstrated. By using nonobese diabetic mice lacking beta cell class I expression, we show that both initiation and progression of insulitis proceeds unperturbed. However, without beta cell class I expression, the vast majority of these mice do not develop hyperglycemia. These findings demonstrate that a direct interaction between CD8 T cells and beta cells is not required for initiation or early disease progression. The requirement for class I on beta cells is a relatively late checkpoint in the development of diabetes. |
