| First Author | Williams MA | Year | 2005 |
| Journal | J Immunol | Volume | 175 |
| Issue | 4 | Pages | 2066-9 |
| PubMed ID | 16081772 | Mgi Jnum | J:107520 |
| Mgi Id | MGI:3621367 | Doi | 10.4049/jimmunol.175.4.2066 |
| Citation | Williams MA, et al. (2005) Cutting edge: a single MHC class Ia is sufficient for CD8 memory T cell differentiation. J Immunol 175(4):2066-9 |
| abstractText | Recent studies have suggested a role for MHC class Ib molecules in providing signals for memory T cell differentiation during the early phases of acute infection. To test this hypothesis, we assessed the development of effector and memory CD8 T cells in transgenic mice expressing a single chain H-2D(d)/beta2-microglobulin (beta2M) fusion protein on a beta2M-deficient background. These mice thus express a single MHC class Ia in the absence of all other beta2M-dependent class Ia and Ib molecules. Following infection with a recombinant vaccinia virus expressing a known D(d)-restricted epitope from HIV-1 gp160, the development of effector and memory cells CD8 T cells was comparable to control mice. Furthermore, these memory cells responded rapidly and robustly to antigenic restimulation. Therefore, we conclude that full CD8 memory differentiation requires only a single MHC class Ia chain, ruling out a requirement for MHC class Ib molecules in this process. |
