| First Author | Wicker LS | Year | 1994 |
| Journal | Diabetes | Volume | 43 |
| Issue | 3 | Pages | 500-4 |
| PubMed ID | 8314024 | Mgi Jnum | J:16999 |
| Mgi Id | MGI:65055 | Doi | 10.2337/diab.43.3.500 |
| Citation | Wicker LS, et al. (1994) Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes 43(3):500-4 |
| abstractText | The role of CD8+ T-cells in the development of diabetes in the nonobese diabetic (NOD) mouse remains controversial. Although it is widely agreed that class II-restricted CD4+ T-cells are essential for the development of diabetes in the NOD model, some studies have suggested that CD8+ T-cells are not required for beta-cell destruction. To assess the contribution of CD8+ T-cells to diabetes, we have developed a class of NOD mouse that lacks expression of beta 2-microglobulin (NOD-B2mnull). NOD-B2mnull mice, which lack both class I expression and CD8+ T-cells in the periphery, not only failed to develop diabetes but were completely devoid of insulitis. These results demonstrate an essential role for CD8+ T-cells in the initiation of the autoimmune response to beta-cells in the NOD mouse. |
