| First Author | Stojakovic M | Year | 2008 |
| Journal | J Immunol | Volume | 181 |
| Issue | 10 | Pages | 6770-8 |
| PubMed ID | 18981094 | Mgi Jnum | J:140950 |
| Mgi Id | MGI:3814954 | Doi | 10.4049/jimmunol.181.10.6770 |
| Citation | Stojakovic M, et al. (2008) Adaptable TCR avidity thresholds for negative selection. J Immunol 181(10):6770-8 |
| abstractText | Central tolerance plays a significant role in preventing autoimmune diseases by eliminating T cells with high and intermediate avidity for self. To determine the manner of setting the threshold for deletion, we created a unique transgenic mouse strain with a diverse T cell population and globally increased TCR avidity for self-peptide/MHC complexes. Despite the adaptations aimed at reducing T cell reactivity (reduced TCR levels and increased levels of TCR signaling inhibitor CD5), transgenic mice displayed more severe experimental allergic encephalomyelitis and lupus. The numbers and activity of natural (CD4(+)CD25(+)) regulatory T cells were not altered. These findings demonstrate that the threshold for deletion is adaptable, allowing survival of T cells with higher avidity when TCR avidity is globally increased. |
