| First Author | Ignatowicz L | Year | 1996 |
| Journal | Cell | Volume | 84 |
| Issue | 4 | Pages | 521-9 |
| PubMed ID | 8598039 | Mgi Jnum | J:58036 |
| Mgi Id | MGI:1346386 | Doi | 10.1016/s0092-8674(00)81028-4 |
| Citation | Ignatowicz L, et al. (1996) The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84(4):521-9 |
| abstractText | Although the thymus produces many immature thymocytes, few of these cells mature. Positive selection has been thought to limit thymocyte development. In thymuses expressing a single MHC/peptide combination, however, surprisingly large numbers of thymocytes are selected to mature. Many of these react with the selecting MHC, bound to other self-peptides. Therefore, the number of thymocytes that mature is limited by the fact that positively selected cells die because they react too well with MHC bound to self-peptides that are not identical to those involved in positive selection. T cells that mature in thymuses expressing a single MHC/peptide ligand react frequently with foreign MHC, suggesting that the repertoire of alpha beta receptors may be more biased toward reaction with MHC than was previously thought. |
