| Primary Identifier | MGI:1928692 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Apaf1 |
| Inheritance Mode | Recessive | Transmission | Germline |
| Strain of Origin | 129P2/OlaHsd | Is Recombinase | false |
| Is Wild Type | false |
| description | Null mutations are lethal, arresting development with phenotypes ascribed to the lack of proper apoptosis, such that too many cells are present, yielding exencephaly and webbed paws. Fas-induced apoptosis, however, appears unaffected in thymocytes, suggesting Apaf1 works by a different mechanism (J:49841). Apaf1 is essential for the activation of other caspase genes. Some phenotypes in Apaf1 mutants overlap with those in mice carrying mutations in Casp3 and Casp9 (J:49840, J:49841). |
| molecularNote | A 4 kb sequence containing an exon that encodes a portion of the nucleotide-binding P loop was replaced by a neomycin cassette. |
