| First Author | Sasaki T | Year | 2023 |
| Journal | iScience | Volume | 26 |
| Issue | 10 | Pages | 107717 |
| PubMed ID | 37744036 | Mgi Jnum | J:341178 |
| Mgi Id | MGI:7532223 | Doi | 10.1016/j.isci.2023.107717 |
| Citation | Sasaki T, et al. (2023) Role of Fyn and the interleukin-6-STAT-3-autophagy axis in sarcopenia. iScience 26(10):107717 |
| abstractText | Sarcopenia is the progressive loss of muscle mass wherein Fyn regulates STAT3 to decrease autophagy. To elucidate the role of inflammation in Fyn-STAT3-dependent autophagy and sarcopenia, here we aimed to investigate the underlying mechanisms using two mouse models of primary and secondary sarcopenia: (1) tail suspension and (2) sciatic denervation. In wild-type mice, the expression of Fyn and IL-6 increased significantly. The expression and phosphorylation levels of STAT3 were also significantly augmented, while autophagic activity was abolished. To investigate Fyn-dependency, we used tail suspension with Fyn-null mice. In tail-suspended wild-type mice, IL-6 expression was increased; however, it was abolished in Fyn-null mice, which maintained autophagy and the expression and ablation of STAT3 phosphorylation. In conclusion, Fyn was found to be associated with the IL-6-STAT3-autophagy axis in sarcopenia. This finding permits a better understanding of sarcopenia-associated metabolic diseases and the possible development of therapeutic interventions. |
