| First Author | Perez-Castro AV | Year | 1998 |
| Journal | Dev Biol | Volume | 201 |
| Issue | 2 | Pages | 135-43 |
| PubMed ID | 9740654 | Mgi Jnum | J:50001 |
| Mgi Id | MGI:1289714 | Doi | 10.1006/dbio.1998.9005 |
| Citation | Perez-Castro AV, et al. (1998) Centromeric protein B null mice are viable with no apparent abnormalities. Dev Biol 201(2):135-43 |
| abstractText | The centromere protein B (CENP-B) is a centromeric DNA/ binding protein. It recognizes a 17-bp sequence motif called the CENP-B box, which is found in the centromeric region of most chromosomes. It binds DNA through its amino terminus and dimerizes through its carboxy terminus. CENP- B protein has been proposed to perform a vital role in organizing chromatin structures at centromeres. However, other evidence does not agree with this view. For example, CENP-B is found at inactive centromeres on stable dicentric chromosomes, and also mitotically stable chromosomes lacking a-satellite DNA have been reported. To address the biological function of CENP-B,we generated mouse null mutants of CENP-B by homologous recombination. Mice lacking CENP-B were viable and fertile, indicating that mice without CENP-B undergo normal somatic and germline development. Thus, both mitosis and meiosis are able to proceed normally in the absence of CENP-B. (C) 1998 Academic Press. |
