| First Author | Chun TH | Year | 2006 |
| Journal | Cell | Volume | 125 |
| Issue | 3 | Pages | 577-91 |
| PubMed ID | 16678100 | Mgi Jnum | J:115867 |
| Mgi Id | MGI:3692335 | Doi | 10.1016/j.cell.2006.02.050 |
| Citation | Chun TH, et al. (2006) A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell 125(3):577-91 |
| abstractText | White adipose tissue (WAT) serves as the primary energy depot in the body by storing fat. During development, fat cell precursors (i.e., preadipocytes) undergo a hypertrophic response as they mature into lipid-laden adipocytes. However, the mechanisms that regulate adipocyte size and mass remain undefined. Herein, we demonstrate that the membrane-anchored metalloproteinase, MT1-MMP, coordinates adipocyte differentiation in vivo. In the absence of the protease, WAT development is aborted, leaving tissues populated by mini-adipocytes which render null mice lipodystrophic. While MT1-MMP preadipocytes display a cell autonomous defect in vivo, null progenitors retain the ability to differentiate into functional adipocytes during 2-dimensional (2-D) culture. By contrast, within the context of the 3-dimensional (3-D) ECM, normal adipocyte maturation requires a burst in MT1-MMP-mediated proteolysis that modulates pericellular collagen rigidity in a fashion that controls adipogenesis. Hence, MT1-MMP acts as a 3-D-specific adipogenic factor that directs the dynamic adipocyte-ECM interactions critical to WAT development. |
