| First Author | Wessendarp M | Year | 2022 |
| Journal | Mitochondrion | Volume | 62 |
| Pages | 85-101 | PubMed ID | 34740864 |
| Mgi Jnum | J:331528 | Mgi Id | MGI:7386955 |
| Doi | 10.1016/j.mito.2021.10.009 | Citation | Wessendarp M, et al. (2022) Role of GM-CSF in regulating metabolism and mitochondrial functions critical to macrophage proliferation. Mitochondrion 62:85-101 |
| abstractText | Granulocyte-macrophage colony-stimulating factor (GM-CSF) exerts pleiotropic effects on macrophages and is required for self-renewal but the mechanisms responsible are unknown. Using mouse models with disrupted GM-CSF signaling, we show GM-CSF is critical for mitochondrial turnover, functions, and integrity. GM-CSF signaling is essential for fatty acid beta-oxidation and markedly increased tricarboxylic acid cycle activity, oxidative phosphorylation, and ATP production. GM-CSF also regulated cytosolic pathways including glycolysis, pentose phosphate pathway, and amino acid synthesis. We conclude that GM-CSF regulates macrophages in part through a critical role in maintaining mitochondria, which are necessary for cellular metabolism as well as proliferation and self-renewal. |
