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Publication : Hmga2 is dispensable for cutaneous squamous cell carcinoma.

First Author  White A Year  2016
Journal  Exp Dermatol Volume  25
Issue  5 Pages  409-12
PubMed ID  26901496 Mgi Jnum  J:316511
Mgi Id  MGI:6837777 Doi  10.1111/exd.12978
Citation  White A, et al. (2016) Hmga2 is dispensable for cutaneous squamous cell carcinoma. Exp Dermatol 25(5):409-12
abstractText  Hmga2 functions as a chromatin-associated factor during development, but is not expressed in most adult tissues. Expression of Hmga2 in adult tissues has been associated with a variety of human cancers. Numerous studies have implicated Hmga2 in epithelial-to-mesenchymal transition (EMT) and cancer progression through gain of function studies, but it is unclear whether Hgma2 is necessary for EMT, tumor formation or tumor progression. We deleted Hmga2 in two mouse models of squamous cell carcinoma and found this gene to be dispensable. In fact, EMT, tumor initiation and progression all appeared to be mostly unaffected by the absence of Hmga2. Tumors lacking the ability to induce Hmga2 proceeded to initiate cutaneous spindle cell and squamous cell carcinomas with all the typical pathological and molecular hallmarks of these cancers.
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