| First Author | Hakem A | Year | 2012 |
| Journal | Blood | Volume | 119 |
| Issue | 15 | Pages | 3495-502 |
| PubMed ID | 22343728 | Mgi Jnum | J:183787 |
| Mgi Id | MGI:5319267 | Doi | 10.1182/blood-2011-07-367532 |
| Citation | Hakem A, et al. (2012) Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis. Blood 119(15):3495-502 |
| abstractText | In addition to its proapoptotic function, caspase-8 is also important for several other processes, including suppressing necroptosis, cell migration, and immune cell survival. In the present study, we report that the loss of caspase-8 in B lymphocytes leads to B-cell malignancies and that the risk for these tumors is further enhanced in the absence of p53. We also report that deficiency of caspase-8 results in impaired cytokinesis and that casp8(-/-) lymphomas display remarkably elevated levels of chromosomal aberrations. Our data support an important role for caspase-8 in the maintenance of genomic integrity and highlight its tumor-suppressive function. |
