| First Author | Kazarian M | Year | 2009 |
| Journal | J Neuroimmunol | Volume | 217 |
| Issue | 1-2 | Pages | 38-45 |
| PubMed ID | 19765830 | Mgi Jnum | J:157319 |
| Mgi Id | MGI:4430658 | Doi | 10.1016/j.jneuroim.2009.08.014 |
| Citation | Kazarian M, et al. (2009) Immune response in lung cancer mouse model mimics human anti-Hu reactivity. J Neuroimmunol 217(1-2):38-45 |
| abstractText | Most patients with paraneoplastic encephalomyelitis/sensory neuronopathy PEM/SN have small-cell lung cancer (SCLC) and develop antibodies against neuronal-specific Hu proteins, which are abnormally expressed in the tumor. Anti-Hu reactivity is present in ~16% of SCLC patients without PEM/SN. Here we test the hypothesis that engineered SCLC-prone mice may exhibit anti-Hu reactivity. We show that tumors from SCLC-prone mice misexpress Hu proteins, and 14% of mice harbor anti-Hu antibodies. Mice appear to show reactivity prior to clinical diagnosis of SCLC. This mouse model system will be useful to study SCLC-associated autoimmunity, its diagnostic value, and the potential protective role of oncoantigen-directed autoantibodies. |
