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Publication : SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse.

First Author  Murray NR Year  2016
Journal  Cancer Cell Volume  30
Issue  4 Pages  505-507
PubMed ID  27728797 Mgi Jnum  J:236719
Mgi Id  MGI:5806989 Doi  10.1016/j.ccell.2016.09.012
Citation  Murray NR, et al. (2016) SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse. Cancer Cell 30(4):505-507
abstractText  In this issue of Cancer Cell, Ferone et al. demonstrate that SOX2 not only drives lung tumor formation but also restricts tumor lineage to squamous cell carcinoma (LSCC), regardless of cell of origin. This novel LSCC model should facilitate identification of key oncogenic drivers and treatment strategies for this lung cancer subtype.
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