| First Author | Cellurale C | Year | 2012 |
| Journal | Cancer Res | Volume | 72 |
| Issue | 2 | Pages | 472-81 |
| PubMed ID | 22127926 | Mgi Jnum | J:181146 |
| Mgi Id | MGI:5308913 | Doi | 10.1158/0008-5472.CAN-11-1628 |
| Citation | Cellurale C, et al. (2012) Role of JNK in mammary gland development and breast cancer. Cancer Res 72(2):472-81 |
| abstractText | cJun NH(2)-terminal kinase (JNK) signaling has been implicated in the developmental morphogenesis of epithelial organs. In this study, we employed a compound deletion of the murine Jnk1 and Jnk2 genes in the mammary gland to evaluate the requirement for these ubiquitously expressed genes in breast development and tumorigenesis. JNK1/2 was not required for breast epithelial cell proliferation or motility. However, JNK1/2 deficiency caused increased branching morphogenesis and defects in the clearance of lumenal epithelial cells. In the setting of breast cancer development, JNK1/2 deficiency significantly increased tumor formation. Together, these findings established that JNK signaling is required for normal mammary gland development and that it has a suppressive role in mammary tumorigenesis. |
