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Allele : Nr3c1<tm3Gsc> nuclear receptor subfamily 3, group C, member 1; targeted mutation 3, Gunther Schutz
Primary Identifier  MGI:1931329 Allele Type  Targeted
Attribute String  Modified isoform(s) Gene  Nr3c1
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  A point mutation was introduced into exon 4 to change alanine codon 474 to threonine (p.A474T). The loxP site flanked neomycin resistance gene cassette that was inserted into intron 3 was removed via Cre-mediated recombination in ES cells prior to blastocyst injection. This mutation causes a defect in GRE-mediated transactivation and prevents dimerization.
  • mutations:
  • Insertion,
  • Intragenic deletion,
  • Nucleotide substitutions
  • synonyms:
  • GR<dim>,
  • GR<D>,
  • GR<dim>,
  • GR<D>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

45 Publication categories





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