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Allele : Pdgfb<tm1Cbet> platelet derived growth factor, B polypeptide; targeted mutation 1, Christer Betsholtz

Primary Identifier  MGI:1933334 Allele Type  Targeted
Attribute String  Null/knockout Gene  Pdgfb
Inheritance Mode  Recessive Transmission  Germline
Strain of Origin  129P2/OlaHsd Is Recombinase  false
Is Wild Type  false
description  Mutants in J:89186 provide a model for microvascular changes that bear striking resemblance to diabetic microangiopathy.
molecularNote  A PGK-neomycin cassette replaced part of exon 3 and all of exon 4. The targeting event is predicted to prevent the formation of a major part of the protein, including cysteine residues involved in all inter- and intramolecular sulfide bridges.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • PDGF-B-,
  • PDGF-B-
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

27 Publication categories