Primary Identifier | MGI:1933334 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Pdgfb |
Inheritance Mode | Recessive | Transmission | Germline |
Strain of Origin | 129P2/OlaHsd | Is Recombinase | false |
Is Wild Type | false |
description | Mutants in J:89186 provide a model for microvascular changes that bear striking resemblance to diabetic microangiopathy. |
molecularNote | A PGK-neomycin cassette replaced part of exon 3 and all of exon 4. The targeting event is predicted to prevent the formation of a major part of the protein, including cysteine residues involved in all inter- and intramolecular sulfide bridges. |