| First Author | Wolfer A | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 3 | Pages | 235-41 |
| PubMed ID | 11224523 | Mgi Jnum | J:75505 |
| Mgi Id | MGI:2176721 | Doi | 10.1038/85294 |
| Citation | Wolfer A, et al. (2001) Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development. Nat Immunol 2(3):235-41 |
| abstractText | Notch proteins influence cell-fate decisions in many developing systems. Several gain-of-function studies have suggested a critical role for Notch 1 signaling in CD4-CD8 lineage commitment, maturation and survival in the thymus. However, we show here that tissue-specific inactivation of the gene encoding Notch 1 in immature (CD25+CD44-)T cell precursors does not affect subsequent thymocyte development. Neither steady-state numbers nor the rate of production of CD4+ and CD8+ mature thymocytes is perturbed in the absence of Notch 1. In addition, Notch 1-deficient thymocytes are normally sensitive to spontaneous or glucocorticoid-induced apoptosis. In contrast to earlier reports, these data formally exclude an essential role for Notch 1 in CD4-CD8 lineage commitment, maturation or survival. |
