Primary Identifier | MGI:1934013 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Hfe |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | 2.5 kb of sequence containing the second and third exons, which encode the alpha1 and alpha2 putative ligand binding domains, were replaced with a floxed PGK neomycin selection cassette. Northern blots prepared with total RNA isolated from kidney and liver tissue did not detect full length mRNA in homozygous mutant mice. |