| First Author | McMahan CJ | Year | 1998 |
| Journal | Immunity | Volume | 9 |
| Issue | 5 | Pages | 637-47 |
| PubMed ID | 9846485 | Mgi Jnum | J:153796 |
| Mgi Id | MGI:4366239 | Doi | 10.1016/s1074-7613(00)80661-5 |
| Citation | McMahan CJ, et al. (1998) RAG reexpression and DNA recombination at T cell receptor loci in peripheral CD4+ T cells. Immunity 9(5):637-47 |
| abstractText | Under most circumstances, allelic exclusion at the T cell receptor (TCR)beta locus is tightly regulated. Here, we describe a system in which TCRbeta allelic exclusion is overcome as a result of V(D)J recombination in peripheral CD4+ T cells. In TCRbeta chain transgenic mice, tolerogen-mediated chronic peripheral selection against cells expressing the transgene leads to surface expression of endogenous TCRbeta chains. Peripheral CD4+ T cells reexpress the recombination activating genes, RAG1 and RAG2, and contain signal end intermediates indicative of ongoing V(D)J recombination. The rescue from deletion of mature T cells expressing newly generated TCRbeta chains suggests that receptor revision plays a role in the maintenance of peripheral T cell tolerance. |
