| First Author | Choi SC | Year | 2013 |
| Journal | J Immunol | Volume | 190 |
| Issue | 3 | Pages | 987-96 |
| PubMed ID | 23267023 | Mgi Jnum | J:192603 |
| Mgi Id | MGI:5465483 | Doi | 10.4049/jimmunol.1202227 |
| Citation | Choi SC, et al. (2013) Mouse IgM Fc Receptor, FCMR, Promotes B Cell Development and Modulates Antigen-Driven Immune Responses. J Immunol 190(3):987-96 |
| abstractText | FcR specific for pentameric IgM (FCMR) is expressed at high levels by B cells. Although circulating IgM has profound effects on responses to pathogens, autoimmunity, and B cell homeostasis, the biologic consequences of its binding to FCMR are poorly understood. We interrogated FCMR contributions to B cell function by studying mice that lack FCMR. FCMR transcripts are expressed at different levels by various B cell subsets. FCMR-deficient mice have reduced numbers of developing B cells, splenic follicular and peritoneal B-2 cells, but increased levels of peritoneal B-1a cells and autoantibodies. After immunization, germinal center B cell and plasma cell numbers are increased. FCMR-deficient B cells are sensitive to apoptosis induced by BCR ligation. Our studies demonstrate that FCMR is required for B cell differentiation and homeostasis, the prevention of autoreactive B cells, and responsiveness to antigenic challenge. |
