| Primary Identifier | MGI:1934015 | Allele Type | Targeted |
| Attribute String | Inserted expressed sequence | Gene | Il4 |
| Transmission | Germline | Strain of Origin | 129S2/SvPas |
| Is Recombinase | false | Is Wild Type | false |
| description | This mutation resulted in mice that express Il4 in a membrane-bound form for use in identifying and characterizing Il4-producing cells. |
| molecularNote | A modified version of exon 4 of the gene was inserted between the last codon and the translational stop site of the gene. This modified version of exon 4 contained a transmembrane anchor. In addition, a neomycin resistance cassette was inserted 150 nucleotides downstream of the polyadenylation signal of the gene. These modifications allowed production of mice that express a membrane-bound form of the protein. |
