| First Author | Barker BR | Year | 2010 |
| Journal | Eur J Immunol | Volume | 40 |
| Issue | 11 | Pages | 3085-96 |
| PubMed ID | 21061439 | Mgi Jnum | J:166660 |
| Mgi Id | MGI:4849290 | Doi | 10.1002/eji.200939939 |
| Citation | Barker BR, et al. (2010) Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responses. Eur J Immunol 40(11):3085-96 |
| abstractText | While it is well established that CD8(+) T cells generated in the absence of CD4(+) T cells mediate defective recall responses, the mechanism by which CD4(+) T cells confer help in the generation of CD8(+) T-cell responses remains poorly understood. To determine whether CD4(+) T-cell-derived IL-21 is an important regulator of CD8(+) T-cell responses in help-dependent and -independent viral infections, we examined these responses in the IL-21Ralpha(-/-) mouse model. We show that IL-21 has a role in primary CD8(+) T-cell responses and in recall CD8(+) T-cell responses in help-dependent viral infections. This effect is due to a direct action of IL-21 in enhancing the proliferation of virus-specific CD8(+) T cells and reducing their TRAIL expression. These findings indicate that IL-21 is an important mediator of CD4(+) T-cell help to CD8(+) T cells. |
