| First Author | Umehara T | Year | 2009 |
| Journal | Congenit Anom (Kyoto) | Volume | 49 |
| Issue | 4 | Pages | 253-7 |
| PubMed ID | 20021484 | Mgi Jnum | J:155797 |
| Mgi Id | MGI:4415739 | Doi | 10.1111/j.1741-4520.2009.00246.x |
| Citation | Umehara T, et al. (2009) Role of interleukin-15 in the development of mouse olfactory nerve. Congenit Anom (Kyoto) 49(4):253-7 |
| abstractText | Interleukin (IL)-15 interacts with components of the IL-2 receptor (R) and exhibits T cell-stimulating activity similar to that of IL-2. In addition, IL-15 is widely expressed in many cell types and tissues, including the central nervous system. We provide evidence of a novel role of IL-15 in olfactory neurogenesis. Both IL-15 and IL-15R alpha were expressed in neuronal precursor cells of the developing olfactory epithelium in mice. Adult IL-15R alpha knockout mice had fewer mature olfactory neurons and proliferating cells than wild-type. Our results suggest that IL-15 plays an important role in regulating cell proliferation in olfactory neurogenesis. |
