| First Author | Grasemann H | Year | 2007 |
| Journal | Respir Physiol Neurobiol | Volume | 159 |
| Issue | 2 | Pages | 227-31 |
| PubMed ID | 17869190 | Mgi Jnum | J:140285 |
| Mgi Id | MGI:3813203 | Doi | 10.1016/j.resp.2007.07.012 |
| Citation | Grasemann H, et al. (2007) Ventilatory responses to acute hypoxia in neurokinin-1 receptor deficient mice. Respir Physiol Neurobiol 159(2):227-31 |
| abstractText | The regulatory effect of substance P on respiration is mediated via neurokinin (NK) receptors. While previous studies suggest that NK-1 receptors are involved, little is known about the role NK-2 receptors in ventilatory responses to hypoxia. Ventilatory responses to acute hypoxia (8% O2 in N2) were measured by indirect plethysmography in unanaesthetized, unrestrained NK-1 receptor gene deficient (NK-1-/-) and wild-type mice. In additional experiments mice were treated with an NK-2 receptor antagonist prior to hypoxic challenge. Resting ventilatory parameters were not different between groups. NK-1-/- mice displayed significantly greater shortening of expiratory time and higher increase of breathing frequency during hypoxia than wild-type mice. Treatment with the NK-2 receptor antagonist SR 48968 (1 mg/kg) resulted in a further shortening of inspiratory and expiratory time in NK-1-/- but not wild-type mice. These results demonstrate that both NK-1 and NK-2 receptors are involved in the modification of ventilation in response to acute hypoxia. |
