| First Author | Itskovich VV | Year | 2003 |
| Journal | J Magn Reson Imaging | Volume | 17 |
| Issue | 4 | Pages | 435-9 |
| PubMed ID | 12655582 | Mgi Jnum | J:299058 |
| Mgi Id | MGI:6490109 | Doi | 10.1002/jmri.10279 |
| Citation | Itskovich VV, et al. (2003) Magnetic resonance microscopy quantifies the disease progression in Marfan syndrome mice. J Magn Reson Imaging 17(4):435-9 |
| abstractText | PURPOSE: To use noninvasive magnetic resonance microscopy (MRM) to examine aneurysmal disease in the mouse model of Marfan syndrome (MFS). MATERIALS AND METHODS: A total of eight wild-type (WT) and MFS mice were imaged using MRM; four of them at three different time points over an 8-week period and the remaining animals were imaged at one time point. The maximal cross-sectional area of the aorta was measured by manual tracing and by automated means from combined cardiac and respiratory-gated bright-blood images. Relationships between aortic size and age and the differences between WT and mutant mice aortic size were established. RESULTS: Maximal cross-sectional aortic areas differed significantly (P < 0.05) between WT and mutant mice for all time points, with MFS mice having larger aortic size. There was a positive correlation between aortic size and age in MFS mice (r = 0.80) with a significant increase from the 14th to the 22nd week (P < 0.05). CONCLUSION: MRM detected the differences in aortic size between WT and mutant mice over time, demonstrating a potential for noninvasive technique for the assessment of potential therapies in MFS mice. |
