| First Author | Sá da Bandeira D | Year | 2022 |
| Journal | Cell Rep | Volume | 40 |
| Issue | 3 | Pages | 111114 |
| PubMed ID | 35858557 | Mgi Jnum | J:327069 |
| Mgi Id | MGI:7326977 | Doi | 10.1016/j.celrep.2022.111114 |
| Citation | Sa da Bandeira D, et al. (2022) PDGFRbeta(+) cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny. Cell Rep 40(3):111114 |
| abstractText | Hematopoietic stem cell (HSC) generation in the aorta-gonad-mesonephros region requires HSC specification signals from the surrounding microenvironment. In zebrafish, PDGF-B/PDGFRbeta signaling controls hematopoietic stem/progenitor cell (HSPC) generation and is required in the HSC specification niche. Little is known about murine HSPC specification in vivo and whether PDGF-B/PDGFRbeta is involved. Here, we show that PDGFRbeta is expressed in distinct perivascular stromal cell layers surrounding the mid-gestation dorsal aorta, and its deletion impairs hematopoiesis. We demonstrate that PDGFRbeta(+) cells play a dual role in murine hematopoiesis. They act in the aortic niche to support HSPCs, and in addition, PDGFRbeta(+) embryonic precursors give rise to a subset of HSPCs that persist into adulthood. These findings provide crucial information for the controlled production of HSPCs in vitro. |
