| First Author | Wei Z | Year | 2023 |
| Journal | Am J Alzheimers Dis Other Demen | Volume | 38 |
| Pages | 15333175231174193 | PubMed ID | 37169734 |
| Mgi Jnum | J:351255 | Mgi Id | MGI:7663213 |
| Doi | 10.1177/15333175231174193 | Citation | Wei Z, et al. (2023) Alterations of Spatial Memory and Gut Microbiota Composition in Alzheimer's Disease Triple-Transgenic Mice at 3, 6, and 9 Months of Age. Am J Alzheimers Dis Other Demen 38:15333175231174193 |
| abstractText | Alzheimer's disease (AD) is a progressive neurological disease. Gut microbial dysbiosis is associated with AD. This study involves the comparative assessment of spatial learning, beta-amyloid peptide accumulation, and fecal microbiota alterations in 3xTg-AD mice from 3 age groups: AD asymptomatic stage (3 m), presymptomatic stage (6 m), and the symptomatic stage of AD (9 m). We demonstrate that spatial memory deficits, brain Abeta accumulation, and weight gain in 3xTg-AD mice gradually appear after 6 months of age. However, the total gut bacterial counts underwent changes from 3 to 6 months of age and were further altered at 9 months of age. Importantly, changes in gut bacteria abundance of Desulfobacterota and Actinobacteriota phyla in 6-month-old mice preceded apparent spatial memory deficits. In summary, Changes in the gut microbial community are one of the mechanisms of early AD pathology. |
