| First Author | Duan J | Year | 2018 |
| Journal | Mol Cell Neurosci | Volume | 89 |
| Pages | 1-8 | PubMed ID | 29577984 |
| Mgi Jnum | J:260969 | Mgi Id | MGI:6152053 |
| Doi | 10.1016/j.mcn.2018.03.009 | Citation | Duan J, et al. (2018) Cystatin C promotes tau protein phosphorylation and causes microtubule instability by inhibiting intracellular turnover of GSK3beta in neurons. Mol Cell Neurosci 89:1-8 |
| abstractText | In Alzheimer''s disease (AD) tau protein hyperphosphorylation causes neurofibrillary tangle formation, microtubule instability and neurodegeneration. Determining the mechanism of tau hyperphosphorylation will provide a better understanding of AD pathology. Cystatin C (CysC) is a risk factor for late-onset AD and its level is upregulated in the brains of AD patients. The role of CysC is AD pathogenesis is not known. In this study, we found that CysC level is upregulated in 3xTg-AD mouse brain. We demonstrate that CysC does not affect cellular Abeta production. However, when overexpressed in neuron (NGF-differentiated PC12 cells), CysC inhibits turnover of GSK3beta, promotes GSK3beta-catalyzed tau phosphorylation at Ser(396/404) and causes microtubule instability. Our data provide a novel insight into the role of CysC in AD pathogenesis. |
