| First Author | Creighton SD | Year | 2022 |
| Journal | Learn Mem | Volume | 29 |
| Issue | 3 | Pages | 71-76 |
| PubMed ID | 35169045 | Mgi Jnum | J:352651 |
| Mgi Id | MGI:7664294 | Doi | 10.1101/lm.053536.121 |
| Citation | Creighton SD, et al. (2022) Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG Alzheimer's disease mice. Learn Mem 29(3):71-76 |
| abstractText | Histone acetylation, catalyzed by histone acetyltransferases, has emerged as a promising therapeutic strategy in Alzheimer's disease (AD). By longitudinally characterizing spatial memory at 3, 6, and 9 mo of age, we show that acute activation and inhibition of the histone acetyltransferase PCAF remediated memory impairments in 3xTG-AD mice in an age-related bidirectional manner. At 3 and 6 mo of age, PCAF activation ameliorated memory deficits. At 9 mo of age, PCAF activation had no effect on spatial memory, whereas PCAF inhibition improved memory deficits in females. This work reveals a complex potential therapeutic role for PCAF in AD, initially benefitting memory but becoming detrimental as the disease progresses. |
