| First Author | Tian S | Year | 2023 |
| Journal | Exp Neurol | Volume | 368 |
| Pages | 114505 | PubMed ID | 37597764 |
| Mgi Jnum | J:340467 | Mgi Id | MGI:7528456 |
| Doi | 10.1016/j.expneurol.2023.114505 | Citation | Tian S, et al. (2023) The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3 x Tg-AD) mouse model strain. Exp Neurol 368:114505 |
| abstractText | As a classic animal model of Alzheimer's disease (AD), the 3 x Tg-AD mouse not only recapitulates most of anatomical hallmarks observed in AD pathology but also displays cognitive alterations in memory and learning tasks. The 3 x Tg-AD can better show the two characteristics of AD, amyloid beta (Abeta) and neurofibrillary tangles (NFT). Therefore, 3 x Tg-AD strain is widely used in AD pathogenesis research and new drug development of AD. In this paper, the construction methods, pathological changes, and treatment characteristics of 3 x Tg-AD mouse models commonly used in AD research are summarized and commented, hoping to provide reference for researchers to choose and establish experimental patterns. |
