| First Author | Xiang J | Year | 2024 |
| Journal | STAR Protoc | Volume | 5 |
| Issue | 1 | Pages | 102788 |
| PubMed ID | 38117656 | Mgi Jnum | J:355509 |
| Mgi Id | MGI:7748937 | Doi | 10.1016/j.xpro.2023.102788 |
| Citation | Xiang J, et al. (2024) Protocol for screening alpha-synuclein PET tracer candidates in vitro and ex vivo. STAR Protoc 5(1):102788 |
| abstractText | Alpha-synuclein (alpha-Syn) positron emission tomography (PET) imaging is a valuable approach for diagnosing and monitoring synucleinopathies-related diseases, such as Parkinson disease. Here, we present a protocol for screening potential alpha-Syn PET tracers using in vitro and ex vivo approaches. We describe steps for employing recombinant pre-formed fibrils and conducting screening procedures on neuronal models, mouse models, and patients' brain tissue sections to assess the specificity and selectivity of the candidate compounds. For complete details on the use and execution of this protocol, please refer to Xiang et al. (2023).(1). |
