| First Author | Pasieka TJ | Year | 2008 |
| Journal | J Virol | Volume | 82 |
| Issue | 12 | Pages | 6052-5 |
| PubMed ID | 18400863 | Mgi Jnum | J:136268 |
| Mgi Id | MGI:3795811 | Doi | 10.1128/JVI.00297-08 |
| Citation | Pasieka TJ, et al. (2008) Enhanced pathogenesis of an attenuated herpes simplex virus for mice lacking Stat1. J Virol 82(12):6052-5 |
| abstractText | Mice lacking the Stat1 interferon signaling gene were infected with herpes simplex virus type 1 (HSV-1) or an attenuated recombinant lacking virion host shutoff (Delta vhs). Delta vhs virus-infected Stat1(-/-) mice showed levels of replication equivalent to that of the wild-type virus-infected control mice but reduced relative to wild-type virus-infected Stat1(-/-) mice. Stat1 deficiency relieves the immunomodulatory deficiency of Delta vhs virus, but not its inherent growth defect. Also Vhs is dispensable for reactivation. |
