| First Author | Stockinger S | Year | 2002 |
| Journal | J Immunol | Volume | 169 |
| Issue | 11 | Pages | 6522-9 |
| PubMed ID | 12444163 | Mgi Jnum | J:119320 |
| Mgi Id | MGI:3701752 | Doi | 10.4049/jimmunol.169.11.6522 |
| Citation | Stockinger S, et al. (2002) Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes. J Immunol 169(11):6522-9 |
| abstractText | Type I IFNs (IFN-alpha/beta) modulate innate immune responses. Here we show activation of transcription factor IFN regulatory factor 3, the synthesis of large amounts of IFN-beta mRNA, and type I IFN signal transduction in macrophages infected with Listeria monocytogenes. Expression of the bacterial virulence protein listeriolysin O was necessary, but not sufficient, for efficient IFN-beta production. Signaling through a pathway involving the type I IFN receptor and Stat1 sensitized macrophages to L. monocytogenes-induced cell death in a manner not requiring inducible NO synthase (nitric oxide synthase 2) or protein kinase R, potential effectors of type I IFN action during microbial infections. The data stress the importance of type I IFN for the course of infections with intracellular bacteria and suggest that factors other than listeriolysin O contribute to macrophage death during Listeria infection. |
