| First Author | Deppong CM | Year | 2012 |
| Journal | Am J Physiol Lung Cell Mol Physiol | Volume | 302 |
| Issue | 1 | Pages | L167-73 |
| PubMed ID | 22003092 | Mgi Jnum | J:183329 |
| Mgi Id | MGI:5318423 | Doi | 10.1152/ajplung.00188.2011 |
| Citation | Deppong CM, et al. (2012) Airway epithelial cells suppress T cell proliferation by an IFNgamma/STAT1/TGFbeta-dependent mechanism. Am J Physiol Lung Cell Mol Physiol 302(1):L167-73 |
| abstractText | Organ-specific regulation of immune responses relies on the exchange of information between nonimmune and immune cells. In a primary culture model of the lung airway, we demonstrate that T cell proliferation is potently inhibited by airway epithelial cells (ECs). This is mediated by activation of the IFNgamma/STAT1 pathway in the EC and transforming growth factor-beta (TGFbeta)-dependent suppression of T cell proliferation. In this way, the EC can restrict the expansion of T cells. Given the constant exposure of the airway to inhaled antigen, this may be important in setting a threshold for the initiation of T cell-dependent immune responses and preventing unwanted, chronic inflammation. |
