| First Author | De Giovanni M | Year | 2020 |
| Journal | Nat Immunol | Volume | 21 |
| Issue | 3 | Pages | 321-330 |
| PubMed ID | 32066949 | Mgi Jnum | J:306849 |
| Mgi Id | MGI:6706711 | Doi | 10.1038/s41590-020-0596-6 |
| Citation | De Giovanni M, et al. (2020) Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4(+) T cells. Nat Immunol 21(3):321-330 |
| abstractText | Differentiation of CD4(+) T cells into either follicular helper T (TFH) or type 1 helper T (TH1) cells influences the balance between humoral and cellular adaptive immunity, but the mechanisms whereby pathogens elicit distinct effector cells are incompletely understood. Here we analyzed the spatiotemporal dynamics of CD4(+) T cells during infection with recombinant vesicular stomatitis virus (VSV), which induces early, potent neutralizing antibodies, or recombinant lymphocytic choriomeningitis virus (LCMV), which induces a vigorous cellular response but inefficient neutralizing antibodies, expressing the same T cell epitope. Early exposure of dendritic cells to type I interferon (IFN), which occurred during infection with VSV, induced production of the cytokine IL-6 and drove TFH cell polarization, whereas late exposure to type I IFN, which occurred during infection with LCMV, did not induce IL-6 and allowed differentiation into TH1 cells. Thus, tight spatiotemporal regulation of type I IFN shapes antiviral CD4(+) T cell differentiation and might instruct vaccine design strategies. |
