| First Author | Hata K | Year | 2016 |
| Journal | FEBS Lett | Volume | 590 |
| Issue | 8 | Pages | 1200-10 |
| PubMed ID | 27013173 | Mgi Jnum | J:232125 |
| Mgi Id | MGI:5776079 | Doi | 10.1002/1873-3468.12161 |
| Citation | Hata K, et al. (2016) Differential regulation of T-cell dependent and T-cell independent antibody responses through arginine methyltransferase PRMT1 in vivo. FEBS Lett 590(8):1200-10 |
| abstractText | Protein arginine methyltransferase 1 (PRMT1), a major PRMT in mammalian cells, has been shown to play a crucial role in multiple biological functions in vitro. To explore the role of PRMT1 in B cells in vivo, we generated B cell-specific PRMT1-deficient (Prmt1(-/-) ) mice using a Cre-loxP system. Prmt1(-/-) mice showed a defect in B-cell development with diminished levels of serum antibodies. Antibody responses in Prmt1(-/-) mice were absent after stimulation with the type 2 T cell-independent antigen NP-Ficoll but intact after stimulation with the T cell-dependent antigen NP-OVA. Our findings comprise the first evidence showing that PRMT1 is necessary for lymphocyte functions in vivo. |
