| First Author | Li Y | Year | 2023 |
| Journal | FEBS Lett | Volume | 597 |
| Issue | 13 | Pages | 1748-1760 |
| PubMed ID | 37171241 | Mgi Jnum | J:345327 |
| Mgi Id | MGI:7568848 | Doi | 10.1002/1873-3468.14633 |
| Citation | Li Y, et al. (2023) The histone H2B ubiquitination regulator Wac is essential for plasma cell differentiation. FEBS Lett 597(13):1748-1760 |
| abstractText | Naive B cells become activated and differentiate into antibody-secreting plasma cells (PCs) when encountering antigens. Here, we reveal that the WW domain-containing adapter protein with coiled-coil (Wac), which is important for histone H2B ubiquitination (ubH2B), is essential for PC differentiation. We demonstrate that B cell-specific Wac knockout mice have severely compromised T cell-dependent and -independent antibody responses. PC differentiation is drastically compromised despite undisturbed germinal center B cell response in the mutant mice. We also observe a significant reduction in global ubH2B in Wac-deficient B cells, which is correlated with downregulated expression of some genes critical for cell metabolism. Thus, our findings demonstrate an essential role of Wac-mediated ubH2B in PC differentiation and shed light on the epigenetic mechanisms underlying this process. |
